Page 12 of 32 · 745 questions tagged clinical-trials.
Details up front: retatrutide · liraglutide. Both of these get recommended confidently by different people, which suggests neither is obviously right. My constraints…
Details up front: SURMOUNT-2 · tirzepatide. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to…
What I have: SURMOUNT-1 · nausea. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…
Numbers first: REDEFINE-1 · early satiety · 2.4 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear…
Every summary of these trials reports the result as though everyone in the active arm reached the assigned dose. "Semaglutide 2.4 mg produced 14.9 % weight loss." But…
The case in front of me: nausea · oral semaglutide · PIONEER-1. I would like to know the limits of what can be inferred from this. What I am trying to avoid is…
The specifics, since they change the answer: SURMOUNT-OSA · nausea · 15 mg. I have the document in front of me and I can read the numbers. What I cannot do is…
The specifics, since they change the answer: FLOW · semaglutide. I want to know whether there is evidence behind this or only repetition. I have checked the obvious…
The specifics, since they change the answer: SURMOUNT-1 · tirzepatide. Somebody stated this to me confidently and I would like to check it before repeating it. I…
My records go back to the first dose with dates, so I can reconstruct the timeline exactly. The figures are clear enough; the question is what they mean and what they…
Details up front: STEP 4 · 2 mg. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree, which…
REDEFINE 1 reported mean weight loss of about 22.7% for CagriSema at 68 weeks, which as far as I can tell is the largest figure any phase 3 obesity trial has…
The specifics, since they change the answer: tirzepatide · minus 80 °C. Somebody stated this to me confidently and I would like to check it before repeating it. I…
Conditions: mazdutide · cagrilintide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a defensible reason…
Setup, so nobody has to ask: tirzepatide · retatrutide. I am trying to choose between two options that are usually discussed as though only one exists. I am not…
The particulars: fatigue · tirzepatide · SURPASS-2. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…
Details up front: a GLP-1 receptor agonist · retatrutide. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…
Conditions: early satiety · oral semaglutide · SOUL. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
Concretely: STEP 4 · 2.4 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change the…
The particulars: headache · semaglutide · SELECT. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
Conditions: tirzepatide · SURPASS-3. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…
Stated plainly: PIONEER-1 · injection-site erythema. I have read the primary source rather than the summary, which has left me with more questions. I understand the…
Setup, so nobody has to ask: dulaglutide · minus 80 °C. This is asserted often enough that I assumed it was established, and then I went looking for the source. I…
Concretely: TRIUMPH-1 · retatrutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result,…