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constipation

Page 3 of 3 · 55 questions tagged constipation.

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55 questions · sorted by votes · page 3 of 3

6 votes 5 answers26k views
What did the placebo arm of TRIUMPH-3 report for constipation?

The particulars: TRIUMPH-3 · constipation. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionsconstipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionsasked by swab_and_wait 13k · 2.0 years ago
5 votes5 answers25k views
Does holding at 12.5 mg for twelve weeks before escalating reduce constipation?

Concretely: 12.5 mg · twelve weeks · constipation. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsconstipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionsdose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questionsasked by thabo_maseko 28k · 2.1 years ago
3 votes5 answers6.5k views
Why does constipation outlast the nausea by months?

It has now persisted for three weeks, which is what moved this from tolerable to worth asking about. I would like the mechanism, because I want to be able to reason…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionsgi-side-effects
gi-side-effects

The gastrointestinal cluster as a whole - nausea, vomiting, diarrhoea, constipation, reflux, early satiety - with trial incidence rates, dropout…

162 questionsglp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questionsasked by swab_and_wait 13k · 9 months ago
2 votes 5 answers11k views
What is the reported incidence of constipation on tirzepatide in SURMOUNT-4?

What I am working with: constipation · tirzepatide · SURMOUNT-4. I have read the primary source rather than the summary, which has left me with more questions. I…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionsclinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionstirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questionsasked by fresh_bac 9.7k · 2.1 years ago
2 votes3 answers6.4k views
Does constipation at week four of orforglipron usually resolve without a dose change?

Concretely: constipation · four · orforglipron. I am trying to do this correctly the first time rather than learn it by getting it wrong. I have already made one…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionsorforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questionsasked by u100_marks 52k · 11 months ago
2 votes0 answers1.9k views
What is the reported incidence of constipation on semaglutide in SUSTAIN-6?

Concretely: constipation · semaglutide · SUSTAIN-6. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionsclinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questionssemaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questionsasked by kelvin_lam 7.6k · 2.0 years ago
1 vote5 answers4.5k views
Does constipation at week two of semaglutide usually resolve without a dose change?

The particulars: constipation · two · semaglutide. Everything I have found on this is either a forum aside or a product page, neither of which I trust. I am…

constipation
constipation

Slowed transit as a consequence of delayed gastric emptying and reduced intake: incidence figures, fibre and hydration evidence, and why it often…

55 questionstitration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questionssemaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questionsasked by mass_shift_18 9.7k · 5 months ago