Page 17 of 21 · 503 questions tagged hplc.
What I am working with: 99.1% · a C18 column · ecnoglutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full…
The case in front of me: an HPLC purity test · aggregation · oral semaglutide. I want to know what the trade-off actually is rather than which option is fashionable.…
Concretely: 98.4% · liraglutide. I want the working, not the result — I need to be able to redo it with different numbers. I care about the precision as well as the…
What I am working with: 97.9% · a C18 column · ecnoglutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full…
Details up front: Medutest · 98.8%. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…
What I have: racemisation · 25 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…
Setup, so nobody has to ask: 97.1% · batch certificate. I have read the primary source rather than the summary, which has left me with more questions. I understand…
What I am working with: 95.2% · mazdutide. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and…
Stated plainly: 97.9% · batch certificate. I have read the primary source rather than the summary, which has left me with more questions. I understand the headline. I…
Details up front: cagrilintide · a C8 column · tirzepatide. I have used one of these for a while and I am considering switching, which requires a reason. What I care…
What I have: 98.8% · a C8 column · oral semaglutide. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…
The specifics, since they change the answer: racemisation · room temperature. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware…
Details up front: racemisation · minus 20 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I…
What I have: racemisation · dulaglutide · minus 80 °C. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring…
The specifics, since they change the answer: tirzepatide · a wide-pore C18 column · mazdutide. The comparison I want does not seem to exist anywhere in a form I can…
The case in front of me: aspartimide formation · liraglutide · 25 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What…
Stated plainly: 99.1% · mazdutide. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it seems…
The case in front of me: oxidation · oral semaglutide · 2–8 °C. This is one of those things that everyone repeats and nobody derives. This matters practically, not…
Concretely: 97.6% · a C4 column · dulaglutide. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single…
This is a recurring problem with one particular shipping lane rather than a one-off. I suspect the honest answer is that it depends, in which case I would like to…
Conditions: aspartimide formation · liraglutide · 40 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the…
The method section is present, which is unusual enough that I want to make use of it. I would like to know the limits of what can be inferred from this. What I am…
What I am working with: dimerisation · 4 °C. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would rather…
Details up front: hydrolysis · dulaglutide · 40 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to…