Page 7 of 21 · 503 questions tagged hplc.
Setup, so nobody has to ask: Janoshik · 95.2%. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…
Numbers first: a GLP-1 receptor agonist · 96.4%. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the…
The particulars: 95.2% · a wide-pore C18 column · mazdutide. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am…
Details up front: mazdutide · a C8 column · survodutide. I have used one of these for a while and I am considering switching, which requires a reason. What I care…
Setup, so nobody has to ask: an HPLC purity test · orforglipron. I have used one of these for a while and I am considering switching, which requires a reason. What I…
The case in front of me: 95.2% · a C4 column · retatrutide. The figures are clear enough; the question is what they mean and what they do not. I can supply the…
What I have: cagrilintide · 95.2%. I can do the algebra. I am not confident about the conversion factors. If there is a standard way to lay this out, I would rather…
The specifics, since they change the answer: liraglutide · a wide-pore C18 column · survodutide. I am trying to choose between two options that are usually discussed…
For reference: VendorInvestigate · 99.1%. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing else in the setup changed,…
Stated plainly: 97.1% · a C18 column · ecnoglutide. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…
The specifics, since they change the answer: deamidation · semaglutide · room temperature. I would like the mechanism, because I want to be able to reason about the…
Setup, so nobody has to ask: 99.4% · a C18 column · ecnoglutide. I have read the primary source rather than the summary, which has left me with more questions. I…
The specifics, since they change the answer: fibrillation · semaglutide · 40 °C. I understand the observation; what I do not understand is the mechanism behind it. I…
What I have: Medutest · 99.1%. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and the date, and I…
Following on from the certification discussion: I want to quantify the damage. Suppose a lab's standard is assigned 95.0% and its true potency is 88.0%. Does my…
Concretely: 99.1% · a C4 column · orforglipron. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…
Numbers first: hydrolysis · orforglipron · 25 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know…
Stated plainly: an HPLC purity test · dulaglutide. I would rather over-plan the first cycle and simplify later. I am prepared to do the work if someone can tell me…
The case in front of me: 97.9% · tirzepatide. Please show the division. I want to check my own against yours. I would like the general form as well as the specific…
The specifics, since they change the answer: fibrillation · ecnoglutide · 4 °C. I understand the observation; what I do not understand is the mechanism behind it. I…
Conditions: 98.8% · method section. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…
What I am working with: 97.6% · mazdutide. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and…
The method section is present, which is unusual enough that I want to make use of it. These are treated as interchangeable and I do not think they are. If both are…
Stated plainly: 97.6% · cagrilintide. The units are where I keep going wrong, so please be explicit about them. I have sanity-checked the order of magnitude and it…