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injection-technique

Page 4 of 4 · 96 questions tagged injection-technique.

96 questions · sorted by votes · page 4 of 4

11 votes0 answers3.1k views
Should I use a 30G needle to draw and something finer to administer?

I have photographs before and after reconstitution if the visual detail matters. I am trying to do this correctly the first time rather than learn it by getting it…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
sterility
sterility

Sterility as a test result rather than an adjective. Covers what a sterility test actually measures, why "sterile filtered" on a document is close…

142 questions
asked by shear_at_the_front 17k · 12 months ago
11 votes0 answers3.1k views
What is the correct way to add diluent so it runs down the vial wall?

I keep a written log of every draw with date, volume and syringe type. I would like to understand the steps well enough to explain them to someone else. I have access…

reconstitution
reconstitution

Taking a lyophilised vial to a solution of known concentration: choice of diluent, volume selection, how to add liquid without shearing the cake,…

313 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
lyophilisation
lyophilisation

Freeze-drying: primary and secondary drying, collapse temperature, the role of bulking agents and cryoprotectants such as mannitol and trehalose,…

17 questions
asked by Dr_Nadia_Farsi 104k · 6 months ago
9 votes 5 answers13k views
Is an 18G drawing needle the right choice for drawing survodutide at 8 mg/mL?

For reference: an 18G drawing needle · survodutide · 8 mg/mL. I am trying to choose between two options that are usually discussed as though only one exists. I am not…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by oona_kekkonen 13k · 21 months ago
9 votes1 answer4.2k views
Does injecting into the flank change absorption enough to matter?

I keep a written log of every draw with date, volume and syringe type. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may…

subcutaneous
subcutaneous

Subcutaneous administration as a route: absorption kinetics from abdomen versus thigh versus upper arm, tissue depth, and why site rotation…

10 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
glp1-mechanism
glp1-mechanism

Receptor-level pharmacology: GLP-1R as a class B GPCR, cAMP and PKA signalling, biased agonism, internalisation and resensitisation, and the…

132 questions
asked by kofi_mensah 18k · 2 months ago
8 votes 5 answers29k views
Does injection speed affect local reactions?

My setup is a refrigerator with a logger and a small work area I wipe down, nothing more. I want to know whether this is a real physical effect or an artefact of how…

injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
injection-site-reaction
injection-site-reaction

Local reactions: erythema, induration, pruritus and nodules. Their relationship to injection depth, diluent composition, benzyl alcohol…

49 questions
subcutaneous
subcutaneous

Subcutaneous administration as a route: absorption kinetics from abdomen versus thigh versus upper arm, tissue depth, and why site rotation…

10 questions
asked by gel_pack_warm 13k · 2.2 years ago
8 votes 5 answers15k views
Is a 25G drawing needle the right choice for drawing mazdutide at 6.67 mg/mL?

Setup, so nobody has to ask: a 25G drawing needle · mazdutide · 6.67 mg/mL. I suspect the honest answer is that it depends, in which case I would like to know on…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by helena_vidmar 8.5k · 9 months ago
8 votes 5 answers4.2k views
Should I use a 29G needle to draw and something finer to administer?

This is the third vial from the same lot, so I can compare against two known-good ones. I have read the obvious sources and they disagree with each other, so I would…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
sterility
sterility

Sterility as a test result rather than an adjective. Covers what a sterility test actually measures, why "sterile filtered" on a document is close…

142 questions
asked by Dr_Tomas_Kral 53k · 6 months ago
7 votes 5 answers12k views
Is a 25G drawing needle the right choice for drawing tirzepatide at 10 mg/mL?

Conditions: a 25G drawing needle · tirzepatide · 10 mg/mL. I would like the axes of comparison first and the recommendation second. I have tried the first option and…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by cal_hennessy 17k · 15 months ago
7 votes 5 answers9.9k views
Is a 30G needle the right choice for drawing mazdutide at 1 mg/mL?

Stated plainly: a 30G needle · mazdutide · 1 mg/mL. Both of these get recommended confidently by different people, which suggests neither is obviously right. My…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by gradient_slope 46k · 5 months ago
6 votes 5 answers22k views
Is a 31G needle the right choice for drawing orforglipron at 5 mg/mL?

What I have: a 31G needle · orforglipron · 5 mg/mL. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by priya_menon 13k · 19 months ago
6 votes 5 answers21k views
Should I use a 31G needle to draw and something finer to administer?

This is the third vial from the same lot, so I can compare against two known-good ones. I have read the obvious sources and they disagree with each other, so I would…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
sterility
sterility

Sterility as a test result rather than an adjective. Covers what a sterility test actually measures, why "sterile filtered" on a document is close…

142 questions
asked by orla_sheridan 18k · 2.4 years ago
6 votes 5 answers7k views
Is a 25G drawing needle the right choice for drawing tirzepatide at 1 mg/mL?

The case in front of me: a 25G drawing needle · tirzepatide · 1 mg/mL. These are treated as interchangeable and I do not think they are. If both are acceptable I…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by Dr_Sara_Kuusela 28k · 12 months ago
6 votes0 answers5.1k views
Is a 31G needle the right choice for drawing dulaglutide at 8 mg/mL?

What I have: a 31G needle · dulaglutide · 8 mg/mL. I want to know what the trade-off actually is rather than which option is fashionable. I would rather have a…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by sasha_ferreira 9.4k · 20 months ago
6 votes 5 answers3.7k views
Is an 18G drawing needle the right choice for drawing semaglutide at 8 mg/mL?

The particulars: an 18G drawing needle · semaglutide · 8 mg/mL. I am trying to choose between two options that are usually discussed as though only one exists. I am…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by dmitri_savchuk 27k · 7 months ago
6 votes 5 answers2.1k views
Is a 29G needle the right choice for drawing survodutide at 5 mg/mL?

The specifics, since they change the answer: a 29G needle · survodutide · 5 mg/mL. I am trying to choose between two options that are usually discussed as though only…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by orla_ferriter 89k · 33 days ago
4 votes 5 answers9.2k views
Is a 30G needle the right choice for drawing tirzepatide at 4 mg/mL?

The case in front of me: a 30G needle · tirzepatide · 4 mg/mL. These are treated as interchangeable and I do not think they are. If both are acceptable I would like…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by dmitri_savchuk 27k · 10 months ago
4 votes 5 answers9k views
Is an 18G drawing needle the right choice for drawing orforglipron at 5 mg/mL?

Numbers first: an 18G drawing needle · orforglipron · 5 mg/mL. I have used one of these for a while and I am considering switching, which requires a reason. What I…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by priya_menon 13k · 2.1 years ago
4 votes 5 answers6.1k views
Is a 27G needle the right choice for drawing liraglutide at 1 mg/mL?

Conditions: a 27G needle · liraglutide · 1 mg/mL. I would like the axes of comparison first and the recommendation second. I have tried the first option and it works;…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by pip_okonjo 13k · 7 months ago
4 votes 5 answers4.9k views
Is a 27G needle the right choice for drawing tirzepatide at 4 mg/mL?

The case in front of me: a 27G needle · tirzepatide · 4 mg/mL. I would like the axes of comparison first and the recommendation second. I have tried the first option…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by Dr_Malik_Osei 19k · 28 days ago
4 votes0 answers574 views
Is a 31G needle the right choice for drawing ecnoglutide at 3.33 mg/mL?

For reference: a 31G needle · ecnoglutide · 3.33 mg/mL. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by tandem_gradient 61k · 1 months ago
3 votes0 answers4.4k views
Is a 29G needle the right choice for drawing semaglutide at 20 mg/mL?

For reference: a 29G needle · semaglutide · 20 mg/mL. The comparison I want does not seem to exist anywhere in a form I can evaluate. I have read the arguments for…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by jo_vandeberg 23k · 17 months ago
3 votes 5 answers3.9k views
Is a 27G needle the right choice for drawing cagrilintide at 10 mg/mL?

Setup, so nobody has to ask: a 27G needle · cagrilintide · 10 mg/mL. I suspect the honest answer is that it depends, in which case I would like to know on what.…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by juan_esquivel 14k · 42 days ago
2 votes 5 answers11k views
Is a 27G needle the right choice for drawing oral semaglutide at 4 mg/mL?

The case in front of me: a 27G needle · oral semaglutide · 4 mg/mL. These are treated as interchangeable and I do not think they are. If both are acceptable I would…

needle-gauge
needle-gauge

Gauge and length selection, the trade-off between draw time and tissue trauma, coring risk with larger-bore needles, and why a fixed-needle…

91 questions
injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
dead-space
dead-space

The volume trapped in the syringe hub and needle after the plunger bottoms out. It is small in absolute terms and large as a fraction of a small…

117 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by jo_vandeberg 23k · 15 months ago
2 votes5 answers3.9k views
Is aspiration indicated for a subcutaneous injection?

I keep a written log of every draw with date, volume and syringe type. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may…

injection-technique
injection-technique

Technique questions: angle, pinch versus flat, aspiration, injection speed, air bubbles, and the handling steps that determine whether you deliver…

96 questions
subcutaneous
subcutaneous

Subcutaneous administration as a route: absorption kinetics from abdomen versus thigh versus upper arm, tissue depth, and why site rotation…

10 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
asked by coldpack_88 50k · 4 months ago