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muscle-loss

Page 2 of 2 · 39 questions tagged muscle-loss.

39 questions · sorted by votes · page 2 of 2

17 votes 5 answers13k views
What fraction of loss on oral semaglutide is lean mass according to PIONEER-4?

The case in front of me: oral semaglutide · PIONEER-4. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by Dr_Ilse_Vandenberg 113k · 19 months ago
16 votes0 answers7.2k views
What fraction of loss on semaglutide is lean mass according to ESSENCE?

The particulars: semaglutide · ESSENCE. I would like help reading this properly rather than being told what conclusion to reach. I have the full report including the…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by mira_sundqvist 7.1k · 11 months ago
15 votes5 answers15k views
What fraction of loss on tirzepatide is lean mass according to SURMOUNT-5?

Setup, so nobody has to ask: tirzepatide · SURMOUNT-5. I would like help reading this properly rather than being told what conclusion to reach. I have the full report…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by gel_pack_warm 13k · 19 months ago
15 votes 5 answers12k views
What fraction of loss on semaglutide is lean mass according to FLOW?

Stated plainly: semaglutide · FLOW. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by teodora_ilic 17k · 7 months ago
14 votes 5 answers15k views
Do the trial populations say anything usable about sarcopenia risk?

The trend is what I care about; individual weeks are obviously noise. I would like to know whether this claim survives contact with evidence. If the answer is "nobody…

sarcopenia
sarcopenia

Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a…

7 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
asked by Dr_Rosalind_Achebe 69k · 19 months ago
12 votes 5 answers26k views
What fraction of loss on orforglipron is lean mass according to ATTAIN-1?

Details up front: orforglipron · ATTAIN-1. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone else’s…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by two_point_four 8.9k · 23 months ago
12 votes5 answers12k views
What fraction of loss on semaglutide is lean mass according to STEP 8?

Numbers first: semaglutide · STEP 8. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by haze_check 9.3k · 9 months ago
12 votes 5 answers7.9k views
How is sarcopenia distinguished from a proportional reduction in lean mass?

I would like to know what to measure as much as what to do. These are treated as interchangeable and I do not think they are. If both are acceptable I would like to…

sarcopenia
sarcopenia

Clinically meaningful loss of muscle mass and function, particularly in older adults on treatment. Distinguishing a proportional reduction from a…

7 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
asked by orla_sheridan 18k · 2 months ago
11 votes5 answers14k views
What fraction of loss on retatrutide is lean mass according to TRIUMPH-1?

What I am working with: retatrutide · TRIUMPH-1. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by shear_at_the_front 17k · 2.0 years ago
11 votes 5 answers7.8k views
What fraction of loss on semaglutide is lean mass according to STEP 3?

Numbers first: semaglutide · STEP 3. This is presented as though it settles something, and I am not convinced it does. I have two documents that appear to disagree,…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by t_oyelaran 79k · 3 months ago
10 votes0 answers1.7k views
Does creatinine fall simply because muscle mass fell?

I have the full paper rather than the abstract, and the supplementary appendix. I can predict the outcome but I cannot explain it, which means I will get the next…

kidney-function
kidney-function

eGFR, creatinine, cystatin C and albuminuria: the acute haemodynamic dip that is not injury, the renal outcome data from the FLOW programme, and…

141 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
bloodwork
bloodwork

Laboratory monitoring: which panels are worth ordering, sensible intervals, reference-range versus optimal-range arguments, and how to read a…

296 questions
asked by ines_delacruz 16k · 5 months ago
8 votes5 answers11k views
What fraction of loss on cagrilintide is lean mass according to REDEFINE-1?

For reference: cagrilintide · REDEFINE-1. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
amylin
amylin

Amylin and its analogues, most prominently cagrilintide, as a satiety mechanism orthogonal to incretin signalling. Includes the pharmacology of…

237 questions
asked by lukas_sedlacek 16k · 7 months ago
6 votes5 answers3.9k views
What fraction of loss on semaglutide is lean mass according to SELECT?

What I have: semaglutide · SELECT. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics change…

lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by Dr_Hanne_Solberg 36k · 4 months ago
4 votes0 answers5.1k views
Does a DEXA repeated every two weeks give me a usable lean-mass trend?

I have three DEXA scans on the same scanner at twelve-week intervals, fasted, same time of day. The comparison I want does not seem to exist anywhere in a form I can…

dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
asked by fibre_or_fragment 13k · 2.0 years ago
4 votes 5 answers4.7k views
Does a DEXA repeated every six weeks give me a usable lean-mass trend?

I would like to know what to measure as much as what to do. I would like the axes of comparison first and the recommendation second. I have tried the first option and…

dexa
dexa

Dual-energy X-ray absorptiometry: what it measures, its precision limits, why hydration state and scan positioning move the numbers, and how to…

39 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
muscle-loss
muscle-loss

Loss of contractile tissue during energy deficit: what fraction of total loss is lean mass, why the commonly quoted figures are measurement…

39 questions
asked by day_seven_trough 6.7k · 15 months ago