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sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether treatment can replace positive airway pressure.

6 questions · sorted by votes

39 votes 5 answers38k views
Is a home sleep test adequate to track change across a course?

I have the full paper rather than the abstract, and the supplementary appendix. I have used one of these for a while and I am considering switching, which requires a…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

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asked by elke_brunner 17k · 21 months ago
30 votes 5 answers16k views
What AHI reduction did SURMOUNT-OSA report, and from which baseline?

I have three data points across nine months, which I hope is enough to see a trend. I have the document in front of me and I can read the numbers. What I cannot do is…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
cardiovascular
cardiovascular

Cardiovascular outcomes: the SELECT major-adverse-event result, SOUL, SUSTAIN 6 and REWIND, how to convert a hazard ratio into an absolute risk…

68 questions
asked by tobias_reint 20k · 11 months ago
26 votes5 answers14k views
Is an AHI improvement durable if weight is regained?

My laboratory results are from the same laboratory each time, drawn fasting, which I gather matters. This is one of those things that everyone repeats and nobody…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
asked by tare_and_weigh 12k · 15 months ago
21 votes 5 answers41k views
How much of an AHI improvement is neck-circumference change?

I am reading the trial table rather than the press release, which is why the numbers differ. I understand the observation; what I do not understand is the mechanism…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
lean-mass
lean-mass

Lean body mass as measured rather than assumed: what DEXA, BIA and air-displacement plethysmography each actually estimate, the body-composition…

127 questions
asked by sample_id 17k · 19 months ago
17 votes0 answers13k views
Does the SURMOUNT-OSA result mean CPAP can be stopped?

I have the full paper rather than the abstract, and the supplementary appendix. I am at the decision point and I would rather think it through than improvise. I would…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
cardiovascular
cardiovascular

Cardiovascular outcomes: the SELECT major-adverse-event result, SOUL, SUSTAIN 6 and REWIND, how to convert a hazard ratio into an absolute risk…

68 questions
asked by Dr_Idris_Coulibaly 33k · 2.0 years ago
2 votes5 answers13k views
Does positional apnoea respond differently to weight loss?

The clinician who ordered the panel was not concerned; I would still like to understand it. I want to know whether this is a real physical effect or an artefact of…

sleep-apnea
sleep-apnea

Obstructive sleep apnoea and the apnoea-hypopnoea index response to weight loss, including the SURMOUNT-OSA dataset and the question of whether…

6 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
weight-regain
weight-regain

Regain after stopping or reducing: the trajectory reported in the withdrawal extensions, how much is fluid, and what the maintenance arms tell us…

10 questions
asked by noor_alhassan 11k · 14 months ago
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