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storage

Page 26 of 30 · 701 questions tagged storage.

701 questions · sorted by votes · page 26 of 30

7 votes1 answer2.9k views
Does a phase-change pack hold a liraglutide shipment for forty-two days in transit?

Details up front: liraglutide · forty-two days. I would rather understand the derivation than memorise the outcome. Two people I asked gave two answers that differ by…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by marcus_thorbjorn 9.4k · 4 months ago
7 votes2 answers2.1k views
Is there any published stability data for oral semaglutide at 37 °C?

For reference: oral semaglutide · 37 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by stopper_core 28k · 17 days ago
7 votes 3 answers1.6k views
Why does hydrolysis accelerate at 2–8 °C rather than proceeding linearly?

Numbers first: hydrolysis · 2–8 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by lyoph_cake 78k · 19 days ago
6 votes5 answers24k views
Why does hydrolysis accelerate at 4 °C rather than proceeding linearly?

Details up front: hydrolysis · 4 °C. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by lucia_marchetti 19k · 2.1 years ago
6 votes 5 answers22k views
Is minus 80 °C an acceptable storage condition for lyophilised dulaglutide?

What I have: minus 80 °C · dulaglutide. I am asking for verification rather than opinion, ideally with something I can read myself. It is possible the evidence exists…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by nadia_kowalczyk 20k · 2.3 years ago
6 votes 5 answers17k views
What is the thermal exposure on a Hangzhou to the Netherlands lane in summer?

Concretely: Hangzhou · the Netherlands. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably comfortable…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by p_mkhize 58k · 2.2 years ago
6 votes5 answers16k views
How long does mazdutide stay within specification at 37 °C once reconstituted?

Numbers first: mazdutide · 37 °C. I can find plenty of assertions about this and almost no reasoning, which is usually a sign that nobody has checked. Assume no…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by lyoph_cake 78k · 2.0 years ago
6 votes 5 answers15k views
What is the thermal exposure on a Guangzhou to Spain lane in summer?

The specifics, since they change the answer: Guangzhou · Spain. I would like help reading this properly rather than being told what conclusion to reach. I have the…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by bridget_nyathi 12k · 11 months ago
6 votes 5 answers14k views
Is room temperature an acceptable storage condition for lyophilised survodutide?

The specifics, since they change the answer: room temperature · survodutide. Somebody stated this to me confidently and I would like to check it before repeating it.…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
survodutide
survodutide

A GLP-1 and glucagon receptor dual agonist with a substantial published MASH dataset. Use this tag for its hepatic endpoints, its dose ladder, and…

225 questions
asked by RP_C18 105k · 16 months ago
6 votes 5 answers14k views
Does a phase-change pack hold a mazdutide shipment for five days in transit?

Concretely: mazdutide · five days. This should be a straightforward calculation and I keep getting two different answers. The numbers are arbitrary; the method is…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by otto_brenner 12k · 2.4 years ago
6 votes 2 answers14k views
Does oral semaglutide adsorb measurably to the vial wall at 4 mg/mL?

For reference: oral semaglutide · 4 mg/mL. I would like the arithmetic checked rather than the conclusion asserted. I have deliberately not used an online calculator…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
content-assay
content-assay

Quantified content: how many milligrams of peptide are actually in the vial, measured against a calibrated reference standard. A separate test…

476 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by jonas_ekstrom 12k · 23 months ago
6 votes 5 answers14k views
How many freeze-thaw cycles will oral semaglutide at 10 mg/mL tolerate?

The particulars: oral semaglutide · 10 mg/mL. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than discover a…

freeze-thaw
freeze-thaw

What repeated freezing does to a peptide in solution: ice-crystal shear at the growing front, freeze-concentration of solutes, pH shifts as buffer…

57 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
oral-glp1
oral-glp1

Oral routes for GLP-1 receptor agonism: peptide formulations rescued by absorption enhancers such as SNAC, and true small molecules that need no…

219 questions
asked by wren_calloway 23k · 15 months ago
6 votes5 answers12k views
Is 2–8 °C an acceptable storage condition for lyophilised ecnoglutide?

For reference: 2–8 °C · ecnoglutide. Somebody stated this to me confidently and I would like to check it before repeating it. I would accept a well-reasoned negative…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by plunger_stop 13k · 19 months ago
6 votes 5 answers11k views
How long does tirzepatide stay within specification at 25 °C once reconstituted?

The particulars: tirzepatide · 25 °C. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than discover a problem…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by Dr_Tomas_Kral 53k · 14 months ago
6 votes 5 answers11k views
Does aspartimide formation dominate for liraglutide held at minus 80 °C?

Concretely: aspartimide formation · liraglutide · minus 80 °C. I want to know whether this is a real physical effect or an artefact of how it is measured. What…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by nadia_kowalczyk 20k · 13 months ago
6 votes 4 answers11k views
What is the thermal exposure on a Hangzhou to New Zealand lane in summer?

Details up front: Hangzhou · New Zealand. I want to understand what this actually establishes, as opposed to what it is being used to imply. My concern is that I am…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by ten_mg_vial 31k · 15 months ago
6 votes 5 answers8k views
Is there any published stability data for liraglutide at minus 80 °C?

For reference: liraglutide · minus 80 °C. I would like to know whether this claim survives contact with evidence. If the answer is "nobody has tested that", I would…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
liraglutide
liraglutide

A once-daily GLP-1 receptor agonist and the compound that established the class. Still relevant for its shorter half-life, its paediatric and…

235 questions
asked by fibre_or_fragment 13k · 22 months ago
6 votes 5 answers7.4k views
Does deamidation dominate for ecnoglutide held at 4 °C?

The particulars: deamidation · ecnoglutide · 4 °C. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by forty_units 16k · 20 months ago
6 votes 5 answers7.3k views
How do I plan for a tirzepatide supply interruption without stockpiling badly?

I have continuous temperature data for the period in question, which is unusual and I would like to use it. I would like to define my thresholds before I have a…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
discontinuation
discontinuation

Stopping treatment: tapering versus abrupt cessation, what the trial withdrawal arms measured, clinically driven stops, and the practical planning…

21 questions
cost-analysis
cost-analysis

Cost arithmetic done honestly: cost per milligram after dead-space loss, list versus net price, comparing a multi-dose vial to a fixed-dose pen,…

260 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by juliette_farnese 13k · 19 months ago
6 votes0 answers6.1k views
What is the thermal exposure on a Zhuhai to the Netherlands lane in summer?

Stated plainly: Zhuhai · the Netherlands. I have the document in front of me and I can read the numbers. What I cannot do is interpret them. I am reasonably…

cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
international-shipping
international-shipping

Cross-border movement of research material: transit lanes and their thermal profiles, tracked versus untracked, declaration accuracy, and what…

471 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
asked by zeynep_arslan 16k · 2.3 years ago
6 votes 3 answers5.3k views
Is 2–8 °C an acceptable storage condition for lyophilised tirzepatide?

Concretely: 2–8 °C · tirzepatide. The claim is plausible, which is exactly why I want to check it. I am able to read a paper if someone points me at one. Has anyone…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
tirzepatide
tirzepatide

A dual GIP and GLP-1 receptor agonist. Questions here cover the SURPASS and SURMOUNT programmes, the practical differences from a pure GLP-1…

370 questions
asked by t_oyelaran 79k · 9 months ago
6 votes 5 answers5.1k views
Is a laboratory refrigerator good enough for storing reconstituted ecnoglutide?

Setup, so nobody has to ask: a laboratory refrigerator · ecnoglutide. I am at the decision point and I would rather think it through than improvise. I would rather…

storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
cold-chain
cold-chain

Keeping material within a temperature window from manufacture to use: phase-change packs versus dry ice, thermal mass, transit-lane temperature…

578 questions
harm-reduction
harm-reduction

Reducing avoidable risk where a decision has already been made: independent verification before use, sterility practice, dose arithmetic checked…

472 questions
ecnoglutide
ecnoglutide

A long-acting GLP-1 receptor agonist with a cAMP-biased signalling profile. A niche tag, mostly used for mechanism questions about biased agonism…

223 questions
asked by vial_five 12k · 4 months ago
6 votes0 answers3.9k views
Why does aggregation accelerate at room temperature rather than proceeding linearly?

The specifics, since they change the answer: aggregation · room temperature. I keep seeing this stated as a fact with no explanation attached, and unexplained facts…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
hplc
hplc

Reverse-phase high-performance liquid chromatography, the workhorse purity method. Column chemistry, mobile-phase choice, gradient slope,…

503 questions
asked by linnea_wahlberg 17k · 9 months ago
6 votes 5 answers3.2k views
How long does orforglipron stay within specification at minus 80 °C once reconstituted?

What I am working with: orforglipron · minus 80 °C. This is a procedural question rather than a theoretical one, and I would like the procedure rather than the…

peptide-stability
peptide-stability

The chemistry of peptide degradation: deamidation, oxidation, hydrolysis, aggregation and fibrillation, and how temperature, pH, ionic strength,…

908 questions
storage
storage

Storage conditions and their evidence base: minus twenty degrees for powder, refrigerated for solution, protection from light, and what the…

701 questions
shelf-life
shelf-life

How long a preparation remains within specification: labelled expiry for a sealed lyophilised vial, beyond-use dating after reconstitution, and…

327 questions
orforglipron
orforglipron

A non-peptide, orally bioavailable small-molecule GLP-1 receptor agonist studied in the ATTAIN programme. It is not a peptide, which changes…

219 questions
asked by ravi_pillai 12k · 3 months ago