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fatigue

Page 3 of 4 · 78 questions tagged fatigue.

78 questions · sorted by votes · page 3 of 4

17 votes 5 answers22k views
What is the reported incidence of fatigue on retatrutide in TRIUMPH-1?

Details up front: fatigue · retatrutide · TRIUMPH-1. I can parse the result. I am less sure what it licenses me to conclude. I have deliberately not looked at anyone…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by tobias_reint 20k · 23 months ago
15 votes 5 answers26k views
What does SURMOUNT-5 tell me about fatigue at the 10 mg dose?

Conditions: SURMOUNT-5 · fatigue · 10 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the specifics…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by shear_at_the_front 17k · 2.1 years ago
15 votes0 answers9.6k views
How do I tell hair thinning from an energy deficit on 1,400 kcal a day?

Concretely: hair thinning · 1,400 kcal. I have two candidate explanations and no way to distinguish them. The same procedure has worked without incident several times…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by ruaidhri_o_shea 25k · 19 months ago
15 votes 4 answers6.7k views
How does cortisol behave in a sustained energy deficit?

I have three data points across nine months, which I hope is enough to see a trend. I suspect the usual explanation for this is wrong, or at least incomplete. I am…

hormones
hormones

Endocrine changes accompanying substantial weight loss: sex hormone binding globulin, testosterone, oestradiol, cortisol and the reproductive…

13 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
asked by liam_bracken 6.9k · 5 months ago
14 votes 5 answers15k views
How do I tell hair thinning from an energy deficit on 900 kcal a day?

What I am working with: hair thinning · 900 kcal. This is not behaving the way I expected and I want to understand the discrepancy before I act on it. I have…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by ravi_pillai 12k · 7 months ago
14 votes 5 answers9.5k views
How do I tell fatigue from an energy deficit on 1,000 kcal a day?

For reference: fatigue · 1,000 kcal. An unexpected observation, and I would like a differential rather than reassurance. The conditions were within what I understood…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by Dr_Nadia_Farsi 104k · 4 months ago
14 votes0 answers6.2k views
Is fatigue on semaglutide dose-dependent or dose-rate dependent?

What I have: fatigue · semaglutide. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to reason…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
semaglutide
semaglutide

A GLP-1 receptor agonist with a fatty-acid-acylated backbone and a roughly one-week half-life, marketed for type 2 diabetes and for weight…

470 questions
asked by sian_llewellyn 65k · 14 months ago
13 votes 5 answers22k views
How do I tell dizziness from an energy deficit on 800 kcal a day?

Numbers first: dizziness · 800 kcal. Before I write this off, I want to check whether it is a known failure mode. I have the lot number, the certificate and the date,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by t_oyelaran 79k · 17 months ago
13 votes 5 answers4k views
What does low energy availability look like in training data?

I have three DEXA scans on the same scanner at twelve-week intervals, fasted, same time of day. I have the document in front of me and I can read the numbers. What I…

exercise
exercise

Training during substantial weight loss: cardiorespiratory work, step count, low energy availability, and how exercise interacts with the appetite…

38 questions
resistance-training
resistance-training

Loaded training as the primary intervention for retaining lean mass in a deficit: minimum effective dose, frequency versus volume, and why…

43 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
asked by Dr_Marek_Zielinski 27k · 4 months ago
12 votes 5 answers28k views
Does holding at 5 mg for three weeks before escalating reduce fatigue?

The particulars: 5 mg · three weeks · fatigue. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by otto_brenner 12k · 21 months ago
12 votes5 answers5.7k views
What does SURMOUNT-5 tell me about fatigue at the 15 mg dose?

What I am working with: SURMOUNT-5 · fatigue · 15 mg. I have read the primary source rather than the summary, which has left me with more questions. I understand the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by gel_pack_warm 13k · 10 months ago
11 votes 5 answers27k views
What did the placebo arm of REDEFINE-1 report for fatigue?

Conditions: REDEFINE-1 · fatigue. I would like to know the limits of what can be inferred from this. What I am trying to avoid is over-reading a single result, which…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
asked by swirl_dont_shake 10k · 2.4 years ago
10 votes5 answers7k views
Does holding at 15 mg for ten weeks before escalating reduce fatigue?

For reference: 15 mg · ten weeks · fatigue. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles…

titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
dose-escalation
dose-escalation

The decision to move up a step: what evidence supports a four-week interval, what happens when you compress it, and how trial protocols handled…

103 questions
asked by bea_forsberg 11k · 15 months ago
10 votes 5 answers4.9k views
What did the placebo arm of SURMOUNT-1 report for fatigue?

The case in front of me: SURMOUNT-1 · fatigue. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if the…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
asked by nynke_dekker 9.4k · 11 months ago
9 votes0 answers5.9k views
Is fatigue on dulaglutide dose-dependent or dose-rate dependent?

Concretely: fatigue · dulaglutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would still…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
dulaglutide
dulaglutide

A once-weekly GLP-1 receptor agonist built on an Fc fusion rather than fatty-acid acylation. Use this tag for questions about the fusion-protein…

200 questions
asked by b_delacroix 43k · 23 months ago
9 votes 4 answers5.3k views
Is fatigue on retatrutide dose-dependent or dose-rate dependent?

The case in front of me: fatigue · retatrutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
retatrutide
retatrutide

An investigational GLP-1, GIP and glucagon receptor tri-agonist, studied in the TRIUMPH programme. Not approved anywhere. Use this tag for…

251 questions
asked by day_seven_trough 6.7k · 5 months ago
8 votes 5 answers9.2k views
Does fatigue at week twelve of mazdutide usually resolve without a dose change?

The case in front of me: fatigue · twelve · mazdutide. I want a method I can write down and repeat, not a rule of thumb. I would rather over-engineer this than…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
mazdutide
mazdutide

A GLP-1 and glucagon receptor dual agonist developed primarily in China, with a distinct dose range and a fast-moving publication record.…

237 questions
asked by teodora_ilic 17k · 16 months ago
7 votes 5 answers20k views
How do I distinguish drug-attributable fatigue from an energy deficit?

No other medication changes, no dietary changes, nothing else obviously confounding. I noticed this today and I have not touched anything since, in case the state is…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
asked by ben_akintola 10k · 17 months ago
7 votes5 answers9.1k views
How do I tell dizziness from an energy deficit on 1,200 kcal a day?

The particulars: dizziness · 1,200 kcal. Something has gone wrong and I would like to know how badly before I decide what to do. Nothing else in the setup changed,…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by lipid_panel_q 36k · 5 months ago
6 votes 5 answers28k views
Does fatigue at week nine of a GLP-1 receptor agonist usually resolve without a dose change?

The particulars: fatigue · nine · a GLP-1 receptor agonist. I have read the obvious sources and they disagree with each other, so I would rather ask people who have…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by ilaria_bertone 33k · 2.0 years ago
6 votes5 answers20k views
How do I tell vomiting from an energy deficit on 800 kcal a day?

Details up front: vomiting · 800 kcal. I have a result I cannot explain, and I would rather diagnose it than guess. I have checked the obvious explanations and…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by siobhan_deasy 9.5k · 20 months ago
6 votes5 answers16k views
How do I tell dizziness from an energy deficit on 1,000 kcal a day?

For reference: dizziness · 1,000 kcal. An unexpected observation, and I would like a differential rather than reassurance. The conditions were within what I…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by Dr_Ravi_Selvarajah 35k · 15 months ago
5 votes5 answers16k views
How do I tell early satiety from an energy deficit on 900 kcal a day?

Conditions: early satiety · 900 kcal. I think I have a problem. I am not yet sure whether it is a real problem or a measurement artefact. I want to know whether this…

fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
nutrition
nutrition

Eating on a suppressed appetite: hitting nutritional targets inside a small energy budget, micronutrient risk, meal structure, and what the trial…

100 questions
electrolytes
electrolytes

Sodium, potassium and magnesium during reduced intake and GI losses: what the symptoms of a shortfall look like, when a panel is worth drawing,…

72 questions
asked by coldbox9 41k · 22 months ago
5 votes 5 answers13k views
What does TRIUMPH-3 tell me about fatigue at the 12 mg dose?

The case in front of me: TRIUMPH-3 · fatigue · 12 mg. The figures are clear enough; the question is what they mean and what they do not. I can supply the numbers if…

clinical-trials
clinical-trials

Reading the primary literature properly: estimands, intention-to-treat versus per-protocol, confidence intervals, absolute versus relative…

745 questions
fatigue
fatigue

Tiredness on treatment: how much is energy deficit, how much is dehydration or electrolyte drift, how much is genuinely drug-attributable, and…

78 questions
titration
titration

Stepwise dose increases over weeks, why the label schedules exist at all, and what tolerability-driven deviation from a schedule looks like in…

456 questions
asked by Dr_Ingrid_Baumgartner 73k · 2.3 years ago