Metabolic dysfunction-associated steatohepatitis: histological endpoints, resolution without worsening fibrosis, fibrosis improvement by stage, non-invasive tests, and biopsy sampling variability.
Stated plainly: lipase · a GLP-1 receptor agonist. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody knows, I would…
What I have: TSH · dulaglutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident the…
The case in front of me: HbA1c · liraglutide. This is one of those things that everyone repeats and nobody derives. This matters practically, not just academically,…
Conditions: potassium · semaglutide. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that come…
Details up front: ApoB · retatrutide. I suspect the usual explanation for this is wrong, or at least incomplete. I am aware this may have a boring answer. I would…
Conditions: GGT · oral semaglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…
Stated plainly: LDL-C · cagrilintide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
The specifics, since they change the answer: albumin-to-creatinine ratio · dulaglutide. I suspect the usual explanation for this is wrong, or at least incomplete. I…
The specifics, since they change the answer: lipase · cagrilintide. The empirical answer seems settled. The explanation does not. If the honest answer is that nobody…
Details up front: ferritin · liraglutide. I want to know whether this is a real physical effect or an artefact of how it is measured. What prompted the question is an…
Stated plainly: eGFR · orforglipron. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident…
Concretely: eGFR · dulaglutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how confident the…
Stated plainly: triglycerides · ecnoglutide. I would like the mechanism, because I want to be able to reason about the cases nobody has written about. I have tried to…
Details up front: ALT · cagrilintide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
Stated plainly: ALT · mazdutide. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me suspicious. My background is…
Every trial in metabolic dysfunction-associated steatohepatitis reports two co-primary endpoints with oddly constructed names: "resolution of steatohepatitis without…
The case in front of me: TSH · retatrutide. I can predict the outcome but I cannot explain it, which means I will get the next case wrong. I would like to know how…
The clinician who ordered the panel was not concerned; I would still like to understand it. I would like help reading this properly rather than being told what…
What I am working with: cystatin C · survodutide. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review…
Every MASH trial reports large falls in ALT and AST alongside the histological endpoints, and the enzyme falls are usually much more impressive-looking than the…
This matters because it predicts what a related molecule should do. This is one of those things that everyone repeats and nobody derives. This matters practically,…
Stated plainly: cystatin C · ecnoglutide. I understand the observation; what I do not understand is the mechanism behind it. I have read the two review articles that…
Setup, so nobody has to ask: LDL-C · a GLP-1 receptor agonist. I keep seeing this stated as a fact with no explanation attached, and unexplained facts make me…
The specifics, since they change the answer: cystatin C · semaglutide. I understand the observation; what I do not understand is the mechanism behind it. I have read…
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