Dr_Colm_Fitzhenry
Cardiology. SELECT, SOUL, and the difference between a hazard ratio and a promise.
69kreputation
249answers
33accepted
8questions
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85tags
117Is there any published stability data for tirzepatide at minus 80 °C?accepted · answered 2 Aug 2025 · peptide-stability, storage, clinical-trials107Is there any published stability data for liraglutide at minus 80 °C?accepted · answered 15 Dec 2024 · peptide-stability, storage, clinical-trials102Is ApoB worth drawing at baseline before starting retatrutide?accepted · answered 24 May 2024 · bloodwork, harm-reduction, a1c102What did the placebo arm of TRIUMPH-1 report for constipation?accepted · answered 15 Dec 2025 · clinical-trials, constipation102What does SURMOUNT-1 report at the 10 mg dose level?accepted · answered 28 Nov 2025 · clinical-trials, dosing-math, titration98Is triglycerides worth drawing at baseline before starting ecnoglutide?answered 30 Nov 2024 · bloodwork, harm-reduction, a1c97What does SURMOUNT-5 tell me about fatigue at the 10 mg dose?accepted · answered 23 Jul 2024 · clinical-trials, fatigue, titration94Is TSH a better monitoring choice than magnesium on tirzepatide?accepted · answered 4 Apr 2026 · bloodwork, kidney-function, lipids90What did the placebo arm of STEP 1 report for headache?answered 28 Dec 2024 · clinical-trials, harm-reduction86What did SURMOUNT-OSA do with participants who could not tolerate a step?accepted · answered 22 Oct 2025 · titration, clinical-trials, gi-side-effects83Does constipation at week ten of semaglutide usually resolve without a dose change?answered 10 Aug 2024 · constipation, titration, semaglutide77Is magnesium a better monitoring choice than TSH on retatrutide?accepted · answered 13 Apr 2025 · bloodwork, kidney-function, lipids74Is there any published stability data for semaglutide at 4 °C?accepted · answered 6 Jan 2026 · peptide-stability, storage, clinical-trials71What does SURMOUNT-OSA report at the 15 mg dose level?answered 28 Feb 2025 · clinical-trials, dosing-math, titration70What is the reported incidence of early satiety on oral semaglutide in SOUL?answered 1 Jul 2024 · gi-side-effects, clinical-trials, oral-glp169What did the placebo arm of STEP 8 report for constipation?accepted · answered 26 Jan 2025 · clinical-trials, constipation68What should a visual inspection of a JEEP vial cover before reconstitution?answered 30 Oct 2024 · vial-inspection, harm-reduction, sterility67Is AST a better monitoring choice than ALT on mazdutide?accepted · answered 21 Apr 2025 · bloodwork, kidney-function, lipids64What did the placebo arm of STEP 5 report for early satiety?accepted · answered 17 Jun 2025 · clinical-trials, gi-side-effects63Is SURMOUNT-5 a fair head-to-head comparison?answered 3 Aug 2025 · tirzepatide, semaglutide, clinical-trials63Why would Janoshik report 96.4% where the supplier certificate says something higher?answered 5 Dec 2024 · purity, hplc, batch-testing62How comparable are a GLP-1 receptor agonist and mazdutide on the evidence available?answered 16 Aug 2024 · clinical-trials, semaglutide, tirzepatide62Is there any published stability data for tirzepatide at minus 20 °C?accepted · answered 6 Dec 2025 · peptide-stability, storage, clinical-trials61How is albuminuria regression measured across a trial?accepted · answered 13 Jul 2025 · renal-outcomes, kidney-function, clinical-trials61What did the placebo arm of REDEFINE-1 report for fatigue?answered 27 Mar 2024 · clinical-trials, fatigue61What does ESSENCE report at the 2 mg dose level?accepted · answered 17 Mar 2025 · clinical-trials, dosing-math, titration60Is magnesium a better monitoring choice than TSH on retatrutide?answered 16 May 2025 · bloodwork, kidney-function, lipids53Why does my ApoB disagree with my LDL-C?accepted · answered 22 Jul 2026 · lipids, bloodwork, cardiovascular52What interval makes sense for repeating LDL-C on a GLP-1 receptor agonist?answered 26 Oct 2025 · bloodwork, harm-reduction, a1c51Is potassium a better monitoring choice than lipase on mazdutide?answered 19 Jun 2025 · bloodwork, kidney-function, lipids50What did the placebo arm of SURMOUNT-4 report for constipation?answered 10 Jun 2025 · clinical-trials, constipation49Why did my triglycerides move after ten weeks on mazdutide?answered 13 Mar 2025 · bloodwork, kidney-function, lipids48Does LDL-C tell me anything about hepatic fat on a GLP-1 receptor agonist?answered 3 Jan 2026 · liver-enzymes, mash, bloodwork48Is triglycerides worth drawing at baseline before starting ecnoglutide?answered 8 Nov 2024 · bloodwork, harm-reduction, a1c48What does STEP 8 actually establish about semaglutide?answered 26 Jun 2026 · clinical-trials, semaglutide, cardiovascular47What did the placebo arm of SURMOUNT-OSA report for hair thinning?answered 22 Mar 2026 · clinical-trials, hair-loss46Do I need to worry about the order I add diluent and swirl?answered 3 Jan 2026 · reconstitution, peptide-stability, injection-technique46How do I reconcile 98.4% from VendorInvestigate with 96.4% from the supplier?answered 22 Dec 2024 · purity, batch-testing, coa46Is triglycerides a better monitoring choice than LDL-C on a GLP-1 receptor agonist?accepted · answered 14 Sept 2024 · bloodwork, kidney-function, lipids46What did REDEFINE 1 report against each of its component arms?answered 23 Jun 2024 · cagrisema, clinical-trials, amylin45Is ferritin a better monitoring choice than ApoB on retatrutide?answered 3 Apr 2025 · bloodwork, kidney-function, lipids44Does hitting a plateau mean the dose needs to go up, or is that the wrong inference?answered 3 Dec 2025 · plateau, dose-escalation, clinical-trials44What is the reported incidence of fatigue on oral semaglutide in PIONEER-4?accepted · answered 19 Oct 2025 · fatigue, clinical-trials, oral-glp143What does SURMOUNT-2 actually establish about tirzepatide?accepted · answered 24 May 2026 · clinical-trials, semaglutide, cardiovascular43What does SURMOUNT-5 tell me about dizziness at the 10 mg dose?answered 14 Jan 2026 · clinical-trials, titration42What is the reported incidence of constipation on semaglutide in ESSENCE?answered 27 Sept 2024 · constipation, clinical-trials, semaglutide41Is WXT worth the price difference against Xi’an Mokemei Biotechnology on measured results?answered 6 May 2025 · vendor-comparison, cost-analysis, batch-testing41What is the reported incidence of vomiting on retatrutide in TRIUMPH-1?answered 1 Oct 2025 · vomiting, clinical-trials, retatrutide40What does STEP 1 actually establish about semaglutide?answered 28 Mar 2025 · clinical-trials, semaglutide, cardiovascular40What is the reported incidence of reflux on semaglutide in STEP 3?answered 5 Jan 2025 · gi-side-effects, clinical-trials, semaglutide40Why did my albumin-to-creatinine ratio move after sixteen weeks on tirzepatide?answered 30 Jul 2024 · bloodwork, kidney-function, lipids38What is the actual trial incidence of nausea by agent and dose, and how comparable are the numbers?answered 7 Jul 2024 · nausea, gi-side-effects, clinical-trials38What is the reported incidence of headache on cagrilintide in REDEFINE-1?answered 2 Jul 2026 · clinical-trials, harm-reduction, amylin38Why do two papers on STEP 8 report different headline figures?answered 11 Jan 2025 · clinical-trials, dosing-math, semaglutide37Does ApoB tell me anything about hepatic fat on retatrutide?answered 15 Aug 2025 · liver-enzymes, mash, bloodwork37What did REDEFINE 1 report against each of its component arms?answered 4 Jul 2024 · cagrisema, clinical-trials, amylin37What did the placebo arm of SUSTAIN-6 report for reflux?answered 3 Feb 2025 · clinical-trials, gi-side-effects37What does FLOW tell me about reflux at the 1 mg dose?answered 6 Oct 2025 · clinical-trials, gi-side-effects, titration36Is ApoB worth drawing at baseline before starting orforglipron?accepted · answered 17 Nov 2024 · bloodwork, harm-reduction, a1c36What counter-ion should I expect on a BCH cagrilintide lot?answered 21 Feb 2026 · acetate-content, purity, content-assay36What does PIONEER-1 tell me about nausea at the 14 mg dose?answered 31 Aug 2024 · clinical-trials, nausea, titration36What is the reported incidence of hair thinning on a GLP-1 receptor agonist in STEP 3?accepted · answered 15 Jun 2025 · hair-loss, clinical-trials36Why do two papers on SURMOUNT-2 report different headline figures?answered 23 Oct 2024 · clinical-trials, dosing-math, semaglutide35Does the SURMOUNT-5 population resemble anyone asking about tirzepatide here?answered 10 Jan 2025 · clinical-trials, harm-reduction, semaglutide35How do I convert the SURMOUNT-4 hazard ratio into an absolute risk reduction?answered 23 Aug 2024 · cardiovascular, clinical-trials, dosing-math34How do I interpret an ApoB trend across three draws?answered 15 Sept 2024 · bloodwork, a1c, lipids34Is there any published stability data for oral semaglutide at minus 80 °C?accepted · answered 14 Jul 2025 · peptide-stability, storage, clinical-trials33Does cystatin C tell me anything about hepatic fat on survodutide?answered 28 Mar 2025 · liver-enzymes, mash, bloodwork33How many times can I pierce a stopper with a 27G needle before coring?answered 19 Mar 2025 · needle-gauge, sterility, vial-inspection33What does ESSENCE report at the 2.4 mg dose level?answered 3 Sept 2025 · clinical-trials, dosing-math, titration33What happens to tirzepatide after three weeks at minus 20 °C in solution?answered 18 Dec 2025 · peptide-stability, storage, shelf-life33What is the reported incidence of hair thinning on oral semaglutide in PIONEER-1?answered 10 Jul 2024 · hair-loss, clinical-trials, oral-glp132Does positional apnoea respond differently to weight loss?answered 6 Aug 2025 · sleep-apnea, clinical-trials, weight-regain32What does FLOW actually establish about semaglutide?answered 22 Sept 2024 · clinical-trials, semaglutide, cardiovascular31Does hydrolysis dominate for orforglipron held at 25 °C?answered 1 Feb 2025 · peptide-stability, storage, hplc31How comparable are semaglutide and liraglutide on the evidence available?answered 16 May 2024 · clinical-trials, semaglutide, tirzepatide31How do I interpret a potassium trend across three draws?answered 4 Jul 2026 · bloodwork, a1c, lipids31How predictive is a Phase 2 dose-response for a Phase 3 result?answered 10 Jun 2026 · clinical-trials, retatrutide, dose-escalation31What did the placebo arm of SELECT report for headache?answered 27 Jan 2026 · clinical-trials, harm-reduction31What did the placebo arm of SOUL report for constipation?answered 26 Sept 2024 · clinical-trials, constipation31What does TRIUMPH-3 report at the 4 mg dose level?accepted · answered 31 May 2026 · clinical-trials, dosing-math, titration31What ovulation-rate change has actually been published in PCOS cohorts?answered 13 Oct 2025 · pcos, hormones, clinical-trials30Does the SOUL population resemble anyone asking about oral semaglutide here?answered 13 Mar 2025 · clinical-trials, harm-reduction, semaglutide30How do I convert the TRIUMPH-3 hazard ratio into an absolute risk reduction?answered 9 Jun 2025 · cardiovascular, clinical-trials, dosing-math30How do I tell constipation from an energy deficit on 1,400 kcal a day?answered 8 Dec 2024 · fatigue, nutrition, electrolytes30How should I budget for a sterility test across a twelve-month retatrutide course?answered 5 Feb 2026 · batch-testing, cost-analysis, janoshik30What is the thermal exposure on a Tianjin to the Netherlands lane in summer?answered 19 Jun 2025 · cold-chain, international-shipping, storage29Can I reconstitute oral semaglutide at 1 mg/mL and still measure a small dose accurately?answered 2 Oct 2024 · diluent-volume, insulin-syringe, dosing-math29How do I interpret a creatinine trend across three draws?answered 18 May 2025 · bloodwork, a1c, lipids29How do I reconcile 95.2% from Janoshik with 98.4% from the supplier?answered 21 Apr 2025 · purity, batch-testing, coa29Is ApoB a better monitoring choice than ferritin on oral semaglutide?answered 22 Mar 2026 · bloodwork, kidney-function, lipids29Is cagrilintide at 4 mg/mL stable enough for two weeks of multi-withdrawal use?answered 15 Oct 2025 · peptide-stability, bacteriostatic-water, shelf-life29What does STEP 4 report at the 2.4 mg dose level?accepted · answered 23 Jan 2025 · clinical-trials, dosing-math, titration28Is GGT a better monitoring choice than albumin-to-creatinine ratio on orforglipron?answered 18 Jun 2025 · bloodwork, kidney-function, lipids28What did the placebo arm of STEP 5 report for early satiety?answered 23 Sept 2025 · clinical-trials, gi-side-effects28What interval makes sense for repeat bloodwork?answered 18 Nov 2024 · bloodwork, a1c, lipids27Does oxidation dominate for liraglutide held at room temperature?answered 8 Feb 2025 · peptide-stability, storage, hplc27What did the placebo arm of SURMOUNT-OSA report for nausea?answered 19 Aug 2025 · clinical-trials, nausea27Would you re-test orforglipron after two weeks at 40 °C, or accept the original certificate?answered 27 Dec 2025 · batch-testing, peptide-stability, coa26How do I interpret a TSH trend across three draws?answered 5 Aug 2024 · bloodwork, a1c, lipids26Is dulaglutide at 8 mg/mL stable enough for sixteen weeks of multi-withdrawal use?answered 21 Sept 2025 · peptide-stability, bacteriostatic-water, shelf-life26Would you re-test oral semaglutide after three weeks at 40 °C, or accept the original certificate?answered 14 Oct 2025 · batch-testing, peptide-stability, coa25Does splitting a 7.5 mg weekly dose of liraglutide across two administrations change anything?answered 7 Jun 2026 · split-dosing, dosing-math, glp1-mechanism25If I reconstitute a 50 mg vial with 5 mL of phosphate-buffered diluent, what concentration do I end up with?answered 1 Dec 2025 · reconstitution, diluent-volume, dosing-math25Is there any published stability data for a GLP-1 receptor agonist at 30 °C?answered 15 Jan 2026 · peptide-stability, storage, clinical-trials25What does STEP 2 tell me about reflux at the 2 mg dose?answered 8 Jul 2025 · clinical-trials, gi-side-effects, titration24Is TSH a better monitoring choice than magnesium on oral semaglutide?answered 4 May 2025 · bloodwork, kidney-function, lipids24What did the placebo arm of FLOW report for reflux?answered 19 Oct 2025 · clinical-trials, gi-side-effects24What did the placebo arm of STEP 8 report for vomiting?answered 5 May 2025 · clinical-trials, vomiting24What did the trials do with participants who could not tolerate a dose step?answered 24 Dec 2024 · titration, clinical-trials, gi-side-effects24What fraction of loss on retatrutide is lean mass according to TRIUMPH-1?answered 27 Sept 2024 · lean-mass, muscle-loss, dexa24What should a visual inspection of a KP vial cover before reconstitution?answered 19 Jan 2025 · vial-inspection, harm-reduction, sterility23Is cystatin C a better monitoring choice than creatinine on a GLP-1 receptor agonist?answered 11 May 2025 · bloodwork, kidney-function, lipids23Is potassium a better monitoring choice than lipase on a GLP-1 receptor agonist?answered 13 Oct 2024 · bloodwork, kidney-function, lipids23What does SURMOUNT-1 report at the 10 mg dose level?answered 17 Nov 2025 · clinical-trials, dosing-math, titration23What does SUSTAIN-6 actually establish about semaglutide?answered 13 Aug 2025 · clinical-trials, semaglutide, cardiovascular22Does the SURMOUNT-2 population resemble anyone asking about a GLP-1 receptor agonist here?answered 21 Feb 2026 · clinical-trials, harm-reduction, semaglutide22Does triglycerides tell me anything about hepatic fat on ecnoglutide?answered 12 Sept 2025 · liver-enzymes, mash, bloodwork22How many vial-days does a 40 mg vial give at 20 mg/mL on a weekly schedule?answered 29 Sept 2025 · dosing-math, cost-analysis, diluent-volume22Is 1 mg weekly a defensible maintenance dose for a GLP-1 receptor agonist?answered 5 Nov 2025 · maintenance-dose, clinical-trials, dosing-math